ADVIA 1800 Chemistry System
Pushing the limit of productivity

The ADVIA^® 1800 Clinical Chemistry System pushes the limit of productivity. Its extensive menu allows integration of testing for clinical chemistry, drugs-of-abuse, therapeutic drug monitoring (TDM) and specific proteins such as cystatin C and CardioPhase^® hsCRP. The ADVIA 1800 Clinical Chemistry System offers:

Throughput of up to 1,800 tests per hour to keep pace with workload peaks
200 basic metabolic panels per hour to meet turnaround-time demands
Large onboard reagent capacity and optional concentrated reagents to reduce interruptions
Optimal standardization of reagents and systems for efficient consumable usage
Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
Automation-ready design: no additional hardware required

Features & Benefits

The ADVIA 1800^® Clinical Chemistry System pushes the limit of productivity in the core lab and meets the turnaround-time (TAT) goals of today’s laboratories. Its extensive menu allows integration of general clinical chemistry testing with testing for drugs-of-abuse, TDM, special chemistry, and specific proteins such as cystatin C and CardioPhase^® hsCRP.

Automation-ready design

Point-in-space aspiration enables connectivity to a track, VersaCell^® System.
Redundant sample loading provides built-in backup and easy handling of non-routine samples.
Direct sampling from track prevents tubes being detained at an analyzer and reduces aliquoting.

Peak productivity

Throughput of up to 1,800 tests per hour provides the speed to keep pace with workload peaks.
Throughput of 200 basic metabolic panels per hour helps to meet turnaround-time demands.
Automatic Sample Retain technology lets you perform reruns and dilutions without the need to retrieve primary tubes.
Consolidate chemistry testing on one system with a comprehensive menu, consistent cycle times, speed, and open application capability.

Total system reliability

Minimal-maintenance ISEs
Robust hardware and simplified software design, with automatic calibration validation and tracking
Advances in reagent onboard stability, calibration frequency, interference reduction and assay linearity expansion
Direct water connection
Remote diagnostics and Inter-Laboratory Quality Control (ILQC) options

Easy efficiency

Large onboard reagent capacity and optional concentrated reagents reduce interruptions.
High-resolution touchscreen delivers push-button operation.
Reagent pause capability and onboard Sample Pause button make loading easy.
Minimal maintenance requirements, including no-maintenance oil bath, reduce hands-on time.
Sample integrity checking, include serum indices reporting, short-sample flagging, and clot detection, reducing the need for manual intervention.

Assays

Download assay menu (pdf) 0.18 MB

Diabetes
Fructosamine
Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology
6-Acetylmorphine (6-AM)^*
Acetaminophen
Amphetamines
Barbiturates
Barbiturates, Serum
Benzodiazepines
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
EDDP^††
Ethyl Alcohol
Ethyl Glucuronide (EtG)^††,§§
Fentanyl^††
Methadone
Opiates
Oxycodone^*
Phencyclidine
Propoxyphene
Salicylate
Tramadol^††
Tricyclic Antidepressants

General Chemistry
Alanine Aminotransferase^†
Alanine Aminotransferase (P5P)^†
Albumin (BCG)^†,‡
Albumin (BCP)
Alkaline Phosphatase
Ammonia
Amylase
Aspartate Aminotransferase^†
Aspartate Aminotransferase (P5P)^†
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)^†
Calcium (CPC)^†Carbon Dioxide (Enzymatic)
Chloride
Cholesterol^†
Cholinesterase
Creatine Kinase
Creatinine^†
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)^†
Glucose (Oxidase)^†
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium^†
Microalbumin
Pancreatic Amylase
Phosphorus^†
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein^†
Total Protein, CSF/Urine
Triglycerides^†
Urea Nitrogen (BUN)^†
Uric Acid^†

Specific Proteins
α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)^§,††
Transferrin

Therapeutic Drug Monitoring
Carbamazepine
Digoxin
Gentamicin
Lamotrigine^††
Levetiracetam^††
Lithium
Methotrexate^**,††
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin

Validity Testing
Creatinine*^,§§
Nitrite*^,§§
Oxidant*^,§§
pH*^,§§
Specific Gravity*^,§§

Technical Specifications

Overview
Type of System	Random, continuous access, batch, discrete processing
Throughput Rate	Up to 1800 tests/hour: 1200 tests/hour colorimetric, 600 tests/hour ISE
Onboard Assay Capacity	55, including 3 ISE

Sample Handling
Sample Tubes	5 mL, 7 mL, 10 mL tubes, 2 mL sample cups
Sample Tray	84 samples, positive sample identification
Sample Integrity Check	Qualitative check for hemolysis, lipemia, and icterus
STAT Sample Loading	84, not dedicated
Bar Codes	Interleaved 2 of 5, Code 39, Code 128, Codabar (NW7)
Auto-repeat	Automatic repeat testing from the retained prediluted sample or original sample
Auto-dilution	Automatic dilution from retained prediluted sample
Auto-reflex Testing	Automatic ability to perform three additional tests based on results of first test
Primary Probe	Liquid-level sensing, crash protection, clot/clog detection, short-sample detection

Microvolume Technology
Automatic Sample Predilution	Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 tests), retained for auto-repeat until results are available
Predilution Tray	120 dilution cuvettes
Original Sample Volume	2-30 μL; average of 2-3 μL per test
Average Reagent Volume	80-120 μL per test
Onboard Storage Capacity	25,200 tests average; usage of concentrated reagents increases maximum capacity

Reaction Area
Reaction Tray	221 reusable plastic cuvettes
Cuvette Optical Path Length	10 mm
Reaction Bath	Inert fluorocarbon oil circulation system, 37°C
Photometer	14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)
Light Source	12 V, 50 W halogen lamp, cooled by forced water circulation
Assay Methods	Endpoint, rate reaction, 2-point rate, multipoint homogeneous immunoassay
Reaction Times	3, 4, 5, 10, 15, and 21 minutes
Automatic Correction	Serum blank, cell blank, measurement point change, sample volume change in reassay
Point Forwarding	Automatically extends linearity over assay range samples

Reagent Handling
Reagent Tray	2 trays, 56 positions each, refrigerated
Reagent Capacity Onboard	52 colorimetric methods
Dispensing System	Two probes with Liquid Level Sensing and Liquid Surface Verification
Reagent Wedges	20, 40, 70 mL bar-code-labeled wedges
Reagent Inventory Management	Tracks tests remaining, lot number, onboard stability, and expiration date
Reagent Dilutions	Capability to dilute concentrated reagents onboard

Open System Capability
Channels	200 channels, includes user-defined applications
3rd Party Applications	Varies by country, can be configured on system

ISE
ISE	Indirect simultaneous measurement of Na+, K+, Cl -
Sample Volume	22 μL for all three tests
Priming	Automatic priming cycle
Electrode Shelf Life	30,000 samples or 3 months
Throughput Rate	600 tests/hour; 200 tubes/hour

Calibration/QC
Calibration Interval	Up to 60 days, tracked by software
Auto-calibration/Auto-QC	User-defined time interval or with new reagent container
View Calibration/QC Data	Graphical display of calibration curves and QC; Siemens Remote Services QC monitoring
Calibration/Control Tray	61 refrigerated positions for calibrators, controls, and diluents

Data Management
Operating Computer	WINDOWS XP, 1 GB RAM, 19-inch touchscreen monitor
System Documentation	Operator manual and assay sheets online
Host Interface	RS 232C bidirectional
Data Storage	70,000 patient tests
Onboard Maintenance Logs	Schedule and monitor routine maintenance activities via software
Host Query	ASCII; system requests work order or batch of work orders from host

General Specifications
Power Requirements	200/220/230/240 V ± 10%, 20 A, 50/60 Hz, 3 KVA
Water Requirements	Deionized water from pressurized water (10-30 psi/169-207 KPa) Average consumption: 30 liters per hour
Drain Requirements	Minimum of 40 liters per hour
Dimensions	44.6 (h) x 58.3 (w) x 34.5 (d) in, 113.3 (h) x 148.0 (w) x 87.6 (d) cm
Weight	1,323 lb (600 kg)
Compliance	UL, cUL, CE
Noise Specifications	Less than 70 db with cover open
Average Heat Output	4,299 BTU/hour @ 50 Hz, 3,023 BTU/hour @ 60 Hz
Operating Temperature Range	18°-30°C/64°-86°F
Ambient Humidity	40-70%

Services & Support

Education & Training

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^*Alliance Application manufactured and distributed by Siemens Healthcare Diagnostics.

^†Also available in concentrated version.

^‡ADVIA Chemistry XPT System supports concentrated version only.

^§Not available for sale in the U.S.

^**Not currently available on the ADVIA Chemistry XPT System.

^††Alliance Application manufactured by third party, distributed by Siemens Healthcare Diagnostics.

‡‡In development, future availability cannot be guaranteed.

^§§Restricted in the U.S. to law enforcement-related use (forensic use only).

Due to local regulations, not all products are available in all countries.

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.