ADVIA 2400 Chemistry SystemThe right balance of speed and efficiency

The ADVIA^® 2400 Clinical Chemistry System manages the most demanding workloads and meets high turnaround-time (TAT) goals. Its menu includes methods for testing drugs-of-abuse, therapeutic drugs (TDM) and new assays such as cystatin C and CardioPhase^® hsCRP. The ADVIA 2400 Clinical Chemistry System offers:

High throughput of up to 2400 tests/hour (1800 photometric and 600 ISE) to manage heavy workloads
Rapid, consistent, 2-second cycle time for faster tube speed and test throughput
User-defined automatic repeat, dilution, and reflex testing
Large onboard reagent capacity and optional concentrated reagents help to minimize intervention demands
Refrigerated onboard storage of controls and reagents for extended stability and increased productivity
Automation-ready design: no additional hardware required

Features & Benefits

The ADVIA 2400 Clinical Chemistry System meets today’s high turnaround-time goals with a throughput of up to 2400 tests/hour. In addition to assays for general and specialty chemistries, its menu includes assays for specific protein measurement, drugs-of-abuse testing (DAT), and therapeutic drug monitoring (TDM). Interesting new assays such as cystatin C, HbA1c with automated sample pretreatment, and CardioPhase^® hsCRP can now be included in your routine testing.

The ADVIA 2400 Chemistry System pushes productivity levels while maintaining the reliability and stability that keep laboratories up and running. A rapid, 2-second probe cycle time maximizes tube speed and test throughput and combines with the system’s efficient automation-readiness to provide the turnaround time needed for high-volume laboratories

Superior Speed and Productivity

Throughput of up to 2400 tests/hour (1800 photometric and 600 ISE) to manage the heaviest workloads
Rapid, consistent, 2-second cycle time
Throughput of 200 tubes per hour, even when running three ISE tests and nine photometric tests per sample
Automatic Sample Retain technology, auto-repeat, auto-dilution, and auto-reflex testing

Automation-ready

Point-in-space aspiration enables connectivity to a track.
Redundant sample loading provides built-in backup and easy handling of non-routine samples.
Direct sampling from track prevents tubes being detained at an analyzer and reduces aliquoting.

Minimal Need for Operator Intervention

Minimal-maintenance ISEs
Large onboard reagent capacity and optional concentrated reagents for fewer interruptions
No-maintenance, 37°C incubation oil bath
Auto-calibration and auto-QC from refrigerated onboard calibrators and controls
Microvolume technology with 32,000 tests onboard and up to 60 days' onboard stability for improved walkaway time. Concentrated reagents for increased maximum capacity.
Remote diagnostics and Inter-Laboratory Quality Control (ILQC) options

Exceptional Reliability

Sample integrity check for icterus, hemolysis, and lipemia
Sample probe with automatic clot/clog detection, liquid-level sensing, short-sample detection, and crash protection
Advances in onboard reagent stability, calibration frequency, reduction in interferences, and expanded assay linearity

Assays

Download assay menu (pdf) 0.18 MB

Diabetes
Fructosamine
Hemoglobin A1c (Enzymatic)

Drugs of Abuse/Toxicology
6-Acetylmorphine (6-AM)^*
Acetaminophen
Amphetamines
Barbiturates
Barbiturates, Serum
Benzodiazepines
Benzodiazepines, Serum
Buprenorphine*
Cannabinoids (THC)
Cocaine Metabolite
Ecstasy
EDDP^††
Ethyl Alcohol
Ethyl Glucuronide (EtG)^††,§§
Fentanyl^††
Methadone
Opiates
Oxycodone^*
Phencyclidine
Propoxyphene
Salicylate
Tramadol^††
Tricyclic Antidepressants

General Chemistry
Alanine Aminotransferase^†
Alanine Aminotransferase (P5P)^†
Albumin (BCG)^†,‡
Albumin (BCP)
Alkaline Phosphatase
Ammonia
Amylase
Aspartate Aminotransferase^†
Aspartate Aminotransferase (P5P)^†
Bilirubin, Direct
Bilirubin, Total
Calcium (Arsenazo)^†
Calcium (CPC)^†Carbon Dioxide (Enzymatic)
Chloride
Cholesterol^†
Cholinesterase
Creatine Kinase
Creatinine^†
Creatinine (Enzymatic)
Gamma-Glutamyltransferase (GGT)
Glucose (Hexokinase)^†
Glucose (Oxidase)^†
HDL Cholesterol
Iron
Lactate
Lactate Dehydrogenase (L-P)
Lactate Dehydrogenase (P-L)
LDL Cholesterol
Lipase
Magnesium^†
Microalbumin
Pancreatic Amylase
Phosphorus^†
Potassium
Sodium
Total Iron Binding Capacity (TIBC)
Total Protein^†
Total Protein, CSF/Urine
Triglycerides^†
Urea Nitrogen (BUN)^†
Uric Acid^†

Specific Proteins
α1-Acid Glycoprotein
α1-Antitrypsin
Antistreptolysin O
Apolipoprotein A1
Apolipoprotein B
β-2 Microglobulin
Complement C3
Complement C4
CRP
CRP, High Sensitivity
CRP, Wide Range
Cystatin C
Ferritin
Haptoglobin
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Lipoprotein(a)
Prealbumin
Rheumatoid Factor
Soluble Transferrin Receptor (sTfR)^§,††
Transferrin

Therapeutic Drug Monitoring
Carbamazepine
Digoxin
Gentamicin
Lamotrigine^††
Levetiracetam^††
Lithium
Methotrexate^**,††
Phenobarbital
Phenytoin
Theophylline
Tobramycin
Valproic Acid
Vancomycin

Validity Testing
Creatinine*^,§§
Nitrite*^,§§
Oxidant*^,§§
pH*^,§§
Specific Gravity*^,§§

Technical Specifications

Overview
Type of System	Random, continuous access, batch, discrete processing
Throughput Rate	Up to 2400 tests/hour: 1800 tests/hour colorimetric, 600 tests/hour ISE
Onboard Assays Capacity	49, including 3 ISE

Sample Handling
Sample Tubes	5 mL, 7 mL, 10 mL, 2 mL sample cups
Sample Tray	84 samples, positive sample identification
Bar Codes	Interleaved 2 of 5, code 39, code 128, Codabar (NW7)
STAT Sample Loading	84, not dedicated
Auto-repeat	Automatic repeat testing from the retained pre-diluted sample
Auto-dilution	Automatic dilution from retained pre-diluted sample
Auto-reflex Testing	Automatic ability to perform three additional tests based on results of first test
Primary Probe	Liquid Level Sensing, Crash Protection, Clot/Clog Detection, Short Sample Detection
Sample Integrity Check	Qualitative check for hemolysis, lipemia and icterus

Microvolume Technology
Automatic Sample Predilution	Samples diluted 1:5 (30 μL sample + 120 μL saline generates up to 15 test results), retained for auto-repeat until results are available
Predilution Tray	120 dilution cuvettes
Original Sample Volume	2–30 µL; system uses an average of 2–3 µL per test
Average Reagent Volume	80–120 µL per test
Onboard Storage Capacity	20,000 tests average; use of concentrated reagents increases maximum capacity

Reaction Area
Reaction Tray	340 reusable plastic cuvettes
Cuvette Optical Path Length	6 mm
Reaction Bath	Inert fluorocarbon oil circulation system, 37°C
Photometer	14 fixed wavelengths (340, 410, 451, 478, 505, 545, 571, 596, 658, 694, 751, 805, 845, and 884 nm)
Light Source	12 V, 50 W halogen lamp, cooled by forced water circulation
Assay Methods	Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay
Reaction Times	3, 4, 5, 10, 15 and 21 minutes
Automatic Correction	Serum blank, cell blank, measurement point change, sample volume change in re-assay
Point Forwarding	Automatically extends linerarity over assay range samples

Reagent Handling
Reagent Tray	Two trays, 50 positions each, refrigerated
Reagent Capacity Onboard	46 colorimetric methods
Dispensing System	Two probes with liquid-level sensing and liquid surface verification
Reagent Wedges	20, 40 and 70 ml bar-code-labeled wedges
Onboard Stability	Up to 60 days
Reagent Inventory Management	Tracks tests remaining, lot number, onboard stability and expiration date
Reagent Dilutions	Capability to dilute concentrated reagents onboard

Open System Capability
Channels	200 channels, includes user-defined applications
Third-party Applications	Varies by country, can be configured on system

ISE
ISE	Indirect simultaneous measurement of Na+, K+, Cl-
Sample Volume	22 µL for all three tests
Priming	Automatic priming cycle
Electrode Life	30,000 samples or 3 months
Throughput Rate	600 tests/hour; 200 tubes/hour

Calibration/QC
Calibration Interval	Up to 60 days, tracked by software
Auto-Calibration/Auto-QC	User-defined time interval or with new reagent wedge
View Calibration/QC Data	Graphical display of calibration curve and QC; Smart Remote Services QC monitoring
Calibration/Control Tray	61 refrigerated positions for calibrators, controls and diluents

Data Management
Operating Computer	WINDOWS XP, flat-panel display
System Documentation	Operator manual and assays sheets online
Host Interface	RS 232C bidirectional
Data Storage	70,000 patient samples
Onboard Maintenance Logs	Schedule and monitor routine maintenance activities via software
Host Query	ASCII; system requests work order or batch of work orders from host

General Specifications
Power Requirements	100/115/200/220/230/240 V ± 10%, 30 A, 50/60 Hz, 3 KVA
Water Requirements	Deionized water
Maximum Water Consumption	40 liters per hour
Drain requirements	Minimum of 10.6 gallons (40 liters) per hour
Dimensions	52.8 (h) x 67.4 (w) x 34.1 (d) in., 134 (h) x 171.1 (w) x 86.7 (d) cm
Weight	1,389 lb (630 kg)
Compliance	cUL, CSA, CE
Noise Specifications	Open cover: less than 70 db, closed cover: less than 45 db
Average Heat Output	5374 BTU/hour
Operating Temperature Range	18–30°C/64–86°F
Ambient Humidity	40–70%

Services & Support

Education & Training

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^*Alliance Application manufactured and distributed by Siemens Healthcare Diagnostics.

^†Also available in concentrated version.

^‡ADVIA Chemistry XPT System supports concentrated version only.

^§Not available for sale in the U.S.

^**Not currently available on the ADVIA Chemistry XPT System.

^††Alliance Application manufactured by third party, distributed by Siemens Healthcare Diagnostics.

^‡‡In development, future availability cannot be guaranteed.

^§§Restricted in the U.S. to law enforcement-related use (forensic use only).

Due to local regulations, not all products are available in all countries.

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.