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Lung Cancer

Lung, Cervix, and Head & Neck Cancers

Squamous Cell Carcinoma (SCC) Assay

Serial SCCA measurements aid in the assessment of disease recurrence, residual disease following treatment, and response to therapy.1 The Siemens Healthineers SCC assay, available on the Atellica® IM Analyzer and ADVIA Centaur® Immunoassay Systems is a valuable tool for the assessment and monitoring of squamous cell carcinoma in the head, neck, lung and cervix.

SCC of the Lungs

SCC of the Cervix

SCC of the Head & Neck

SCC Assay

Squamous Cell Carcinomas (SSC) is an epithelial malignancy that can arise from different tissue types including lung, cervix, esophagus, anal canal, skin, and head and neck.2 Squamous Cell Carcinoma Antigen (SCCA) concentrations are elevated in the blood of patients with cervical, lung, and head and neck cancers. More than 90% of head and neck cancers, 30% of Non-Small Cell Lung cancers2 and 80% of cervical cancers are SCCs.3 Advanced stages of these cancers are associated with higher SCCA concentrations especially in lung and cervix.

SCC of the Lungs 

SCC of the Cervix

SCCA is considered the most useful marker for cervical SCC. The European Group of Tumor Markers (EGTM) recognizes SCCA as the tumor marker of choice for the follow-up of cervical cancer. Most cases are caused by infection with human papillomavirus (HPV), which is preventable with a vaccine.

SCC of the Head and Neck (SCCHN)

SCCA is used as a tumor marker for recurrence of squamous cell carcinoma in various sites, including head and neck. Studies suggest that its high serum levels are correlated to some clinical features, such as nodal metastasis.
Atellica SCC Assay Kit

Atellica® IM and ADVIA Centaur® SCC Assay*

The Siemens Healthineers SCC assay can accurately detect SCCA concentrations, which in conjunction with other clinical and laboratory findings, aids clinicians in treating their patients with squamous cell carcinomas.

  • Rapid and precise measurement of SCC antigen concentrations to monitor disease progression and treatment.
  • Utilizes trusted Acridinium Ester, technology, coupled with two highly specific monoclonal antibodies. 
  • Confidence in results with an assay that detects equimolar SCCA1 and SCCA2 enabling measurement of total SCCA.16

    *Not available for sale in the U.S. Product availability varies by country.

    1. Henry RJW, et al. SCC tumor marker and its relationship to clinical stage in squamous cervical cancer. Aust NZl Obstet Gynaecol. 1987;27:338-40.

    2. Yan W, Wistuba I, et al. Squamous cell carcinoma - similarities and differences among anatomical sites. Am J Cancer Res. 2011;1(3):275-300.

    3. https://www.ajmc.com/view/a-primer-on-cervical-cancer-and-current-standards-of-care (accessed 2022 Oct 13)

    4. https://www.healthline.com/health/lung-cancer/types-of-non-small-cell-lung-cancer

    5. Zappa C, Mousa SA. Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res. 2016;5(3):288-300

    6. Thandra KC. Epidemiology of lung cancer. Contemp Oncol (Pozn). 2021;25(1):45-52. doi:10.5114/wo.2021.103829

    7. ECIS European Cancer Information System. https://ecis.jrc.ec.europa.eu/

    8. Smoking Facts, Statistics & Side Affects 2022. https://www.allencarr.com/easyway-stop-smoking/smoking-facts/

    9. Cataltepe S, et al. Co-expression of the squamous cell carcinoma antigens 1 and 1 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem. 2000;48(1):113-22.

    10. Molina R, et al, Assessment of a Combined Panel of Six Serum Tumor Markers for Lung Cancer, J Respir Crit Care Med Vol 193, Iss 4, pp 427–437, Feb 15, 2016

    11. Bruijn HWA, et al The clinical value of squamous cell carcinoma antigen in cancer of the uterine cervix. Tumour Biol 1998;19:505–16.

    12. https://www.who.int/news-room/fact-sheets/detail/cervical-cancer

    13. https://www.webmd.com/cancer/cervical-cancer/cervical-cancer

    14. British Journal of Cancer (2018) 118, 72–78 | doi: 10.1038/bjc.2017.390

    15. Johnson, D.E., Burtness, B., Leemans, C.R. et al. Head and neck squamous cell carcinoma. Nat Rev Dis Primers 6, 92 (2020). https://doi.org/10.1038/s41572-020-00224-3

    16. Siemens Healthineers Atellica IM SCC IFU 021-530_EN Rev. 01, 2022-04