The role of biomarkers in inflammatory disease in the CNS (kappaFLC & sNFL)

The measurement of kappa free light chain (κFLC) in cerebrospinal fluid (CSF) and serum is a newer but already well-established and sensitive biomarker to detect intrathecal immunoglobulin synthesis. Recently it has been proposed to use κFLC in CSF as a primary exclusion marker for intrathecal inflammation, which would significantly change the workflow for neurological patients.

This webinar explains the concept of excluding intrathecal inflammation by measuring kFLC in CSF and serum using the kFLC index. It also elaborates on the opportunity of serum neurofilament light chains (sNfL) as a promising biomarker for monitoring disease activity in neurological disease such as multiple sclerosis.