INNOVANCE Antithrombin AssayState-of-the-art antithrombin testing
The INNOVANCE® Antithrombin assay is a state-of-the-art reagent for automated measurement of antithrombin activity levels. The ready-to-use reagent offers improved reagent management and shows excellent sensitivity for the detection of antithrombin deficiencies, congenital or acquired.
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Orlando C, Heylen O, Lillens W, et al. Antithrombin heparin binding site deficiency: a challenging diagnosis of a not so benign thrombophilia. Thromb Res. 2015;135:1179-85.
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Kovacs B, Bereczky Z, Olah Z, et al. The superiority of anti-FXa assay over anti-FIIa assay in detecting heparin-binding site antithrombin deficiency. Am J Clin Pathol. 2013;140(5):675-9.
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Gindele R, Selmeczi A, Olah Z, et al. Clinical and laboratory characteristics of antithrombin deficiencies: a large cohort study from a single diagnostic center. Thromb Res. 2017;160:119-28.
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More information on the assay’s sensitivity can be found in the brochure.
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Not available for sale in the U.S.
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Dependent upon individual analyzer performance.
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Van Cott E, Orlando C, Moore GW, Cooper PC, Meijer P, Marlar R. Recommendations for clinical laboratory testing for antithrombin deficiency; communication from the SSC of the ISTH. J Thromb Haemost. 2020;18:17-22.
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Rühl H, Reda S, Müller J, et al. Activated factor X-based versus Thrombin-Based Antithrombin Testing in Thrombophilia Workup in the DOAC era. Thromb Haemost. 2018;118:381–7.
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Merz M, Böhm-Weigert M, Braun S, et al. Clinical multicenter evaluation of a new FXa-based Antithrombin assay. Int Jnl Lab Hem 2011;33:498-503.
Assay performance can vary from country to country as well as with the system application of the respective assay. The values listed above are provided as examples only.
Product availability varies from country to country and is subject to varying regulatory requirements.
Atellica, Berichrom, BCS, INNOVANCE, PSI, and all associated marks are trademarks of Siemens Healthcare Diagnostics Inc., or its affiliates. All other trademarks and brands are the property of their respective owners.
CN Systems refers to Automated Blood Coagulation Analyzer CN-3000 and Automated Blood Coagulation Analyzer CN-6000. CN-3000 and CN-6000 Systems refer to Automated Blood Coagulation Analyzer CN-3000 and Automated Blood Coagulation Analyzer CN-6000 respectively.
CS-2500 and CS-5100 Systems refer to Automated Blood Coagulation Analyzer CS-2500 and Automated Blood Coagulation Analyzer CS-5100 respectively.
CA-660 refers to Automated Blood Coagulation Analyzer CA-660.