A 71-year-old male with history of memory loss was referred for PET/CT imaging to evaluate beta-amyloid plaque burden. This case demonstrates the clinical utility of Biograph Vision™ PET/CT imaging and syngo.PET Amyloid Plaque quantification in the evaluation of beta-amyloid plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer’s disease (AD) and other causes of cognitive decline.