Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h
Authors: Cullen L., Apple F., et. al.
2024 Study Published in the European Heart Journal
New international multicenter study showcasing the impact of the Atellica® VTLi high-sensitivity troponin I (hs-cTnI) assay in the emergency assessment of patients with suspected acute myocardial infarction (AMI).
Study Objective and Key Findings
Objective
- Evaluate safety and efficacy of the 0-2h strategy utilizing the Atellica VTLi point-of-care (POC) high-sensitivity cardiac troponin I (hs-cTnI) assay in the emergency assessment of patients with suspected AMI.
Key Findings
- A 0/2-h algorithm using Atellica VTLi hs-cTnI assay for evaluation of patients with suspected AMI was highly predictive and safe.
- The 2-h algorithm defined 66.1% as low risk with a sensitivity of 98.8% [95% confidence interval (CI) 89.3%–99.9%] and a negative predictive value of 99.9 (95% CI 99.2%–100%) for index AMI in the derivation cohort.
- Short turnaround time achievable with the Atellica VTLi (8 minutes to test results) POC may expedite patient stratification and management in emergency departments, enhancing overall efficiency and patient care.
Test your knowledge
What percentage (range) of suspected ACS patients could be assessed “low risk” based on VTLi hs-cTnI test results per the recent publication in European Heart Journal by Cullen L. et al?
Determination of a wholeblood single-test low-risk threshold for a point-of-care high-sensitivity troponin assay
Authors: Pickering J., Than M., et.al.
2024 Study Published in the Emergency Medicine Journal
To enhance care delivery in emergency departments (EDs) through faster risk-stratification methods, this study showcases initial findings from the ICare-FASTER interventional clinical trial. Focusing on point-of-care technology within an Accelerated Diagnostic algorithm (0-2 h), it discusses the clinical utilization of this algorithm conducted at Christchurch Hospital in New Zealand and highlights its impact on reducinTo enhance care delivery in emergency departments (EDs) through faster risk-stratification methods, this study showcases initial findings from the ICare-FASTER interventional clinical trial. Focusing on point-of-care technology within an Accelerated Diagnostic algorithm (0-2 h), it discusses the clinical utilization of this algorithm conducted at Christchurch Hospital in New Zealand and highlights its impact on reducing the overall length of stay for patients.
Study Objective and Key Findings
Objective
- To determine a safe low-risk threshold for a point-of-care high-sensitivity troponin I (POC-hsTnI) assay specifically for use in New Zealand emergency departments (EDs).
Key findings
- High Sensitivity and NPV:
- VTLi <7 ng/L with no new ECG ischemia and blood draw ≥3 hours from symptom onset demonstrated 99.2% sensitivity and 99.7% negative predictive value.
- Strong Correlation with Lab Results:
- POC-hsTnI assay results showed a high correlation (r=0.95) with laboratory hsTnI results.
- Expedited Decision-Making:
- With an 8-minute turnaround time, the POC-hsTnI assay can significantly reduce the time needed for decision-making in suspected acute myocardial infarction cases.
Test your knowledge
Which rapid algorithm/s with high-sensitive troponin assays do ESC guidelines recommend to rule-in and rule-out NSTEMI?