Cryoablation of an adrenal metastasis under CT guidance

Michael Kostrzewa, MD; Florian Messmer, MD
Interventional Radiology, Kantonsspital Baden, Switzerland

2024-06-25

An 85-year-old male patient, suffering from bronchial carcinoma, was diagnosed with a left adrenal mass. It was progressive in size, despite prior radiotherapy, therefore being highly suggestive of a metastasis. The patient was admitted for cryoablation.

The patient was placed in left lateral decubitus to prone position. The intervention was performed under general anesthesia.

The metastasis in the left adrenal gland, measuring approx. 5 cm in diameter, was seen in a biphasic (arterial and venous) contrast CT scan for planning, showing peripheral enhancement in the venous phase. The lesion was closely located between the upper pole of the left kidney and the abdominal aorta.

The access routes were planned using myNeedle Guide 3D. A total of six cryoprobes (Boston Scientific IceRod 1.5 CX 90°) were placed in the lesion using dorsal paravertebral or intercostal paths. Due to the lack of alternative access routes, three probes had to be placed using a transpulmonary approach. A 10-minute freeze cycle was carried out, followed by passive thawing for 9 minutes. Then another 10-minute freeze cycle was followed by an active thawing of 1 minute. The growth of the ice ball and the ablation zone were monitored at 8-minute intervals by CT scanning using i-spiral. Tract ablation was performed at the removal of the probes to prevent track seeding.

A biphasic (arterial and venous) control contrast CT scan was performed, showing a hypodense area in the ablation zone without contrast enhancement of the adrenal gland. No signs of post-interventional complications, especially neither bleeding nor pneumothorax, were seen.

The patient was dismissed from the hospital the day after the procedure. A follow-up CT, three months after the cryoablation, showed complete devascularization of the lesion with no signs of recurrence.

Axial images (2 mm) prior to the cryoablation show a metastatic lesion in the left adrenal gland, measuring approx. 5 cm in diameter, with peripheral enhancement, closely located between the upper pole of the left kidney and the abdominal aorta. After the cryoablation, a hypodense area in the ablation zone without contrast enhancement is shown.
Courtesy of Interventional Radiology, Kantonsspital Baden, Switzerland

Fig. 1: Axial images (2 mm) prior to the cryoablation (Fig. 1a, arterial phase and 1b, venous phase) show a metastatic lesion in the left adrenal gland, measuring approx. 5 cm in diameter, with peripheral enhancement (arrow), closely located between the upper pole of the left kidney and the abdominal aorta. After the cryoablation (Fig. 1c, arterial phase and 1d, venous phase), a hypodense area in the ablation zone without contrast enhancement is shown.

An axial image from a follow-up contrast CT scan, 3 months after the cryoablation procedure, showed complete devascularization of the lesion with no signs of recurrence.
Courtesy of Interventional Radiology, Kantonsspital Baden, Switzerland

Fig. 2: An axial image from a follow-up contrast CT scan, 3 months after the cryoablation procedure, showed complete devascularization of the lesion (arrow) with no signs of recurrence.

A photo shows two fan beam laser projectors that best visualize the geometry of the needle path are combined to project the entry point and the angulation of the path. A cinematic volume rendered image shows the position of the 6 cryoprobes in three dimensions.
Courtesy of Interventional Radiology, Kantonsspital Baden, Switzerland

Fig. 3: A photo (Fig. 3a) shows two fan beam laser projectors that best visualize the geometry of the needle path are combined to project the entry point and the angulation of the path. A cinematic volume rendered image (Fig. 3b) shows the position of the 6 cryoprobes in three dimensions.

Cryoablation applies alternating cycles of freezing and thawing to cause mechanical stress on the cellular membranes from intracellular ice crystal formation and hypotonic cell disruption. Adrenal ablations are usually performed under CT guidance. The success of the procedure, as well as the prevention of nontarget thermal injury, highly rely on precise probe positioning, meticulous preprocedural planning and intraprocedural monitoring.

Studies have shown that cryoablation has a lower risk of a hypertensive crisis than microwave ablation. [1,2] During the cryoablation procedure, the ice ball growing, and thus the ablation area, can be clearly monitored on CT imaging. Potential damages to risk structures, such as vessels (a renal artery in this case) in the target area can be carefully avoided. The trajectories of six cryoprobes are planned on multiplanar reformats (MPRs) using myNeedle Guide 3D. This method is particularly helpful in planning a double angulated access path. The planned path is individually transferred by “one-click” to the laser guidance system, myNeedle Laser, integrated in both software and hardware of the CT scanner, SOMATOM X.ceed. Two of the four laser projectors installed on the gantry are utilized for visualizing the probe. Specifically, these two projectors are combined to visualize both the entry point and trajectory angle of the probe accurately. The selection criteria for these two adjacent laser projectors prioritize precision in entry point and trajectory angle visualization. During the probe placement, short sequential (i-sequence) or spiral (i-spiral) scans are performed to monitor the progress. With the help of the laser guidance system, the workflow of the probe positioning becomes more efficient, facilitating a successful placement of six cryoprobes in the tumor.

Scanner

Scan area

Mid abdomen

Mid abdomen

Scan mode

Spiral mode
(planning)
Arterial/venous

Spiral mode
(planning)
Arterial/venous

Scan length

212 / 216 mm

156 / 150 mm

Scan direction

Cranio-caudal

Cranio-caudal

Scan time

3.3 / 3.6 s

2.4 / 2.3 s

Tube voltage

100 kV

100 kV

Effective mAs

91 / 107 mAs

93 / 110 mAs

Dose modulation

CARE Dose4D

CARE Dose4D

CTDIvol

4.8 / 5.6 mGy

4.8 / 5.7 mGy

DLP

114 / 141 mGy*cm

88 / 102 mGy*cm

Rotation time

0.5 s

0.5 s

Pitch

0.8

0.8

Slice collimation

128 x 0.6 mm

128 x 0.6 mm

Slice width

2 mm

2 mm

Reconstruction increment

2 mm

2 mm

Reconstruction kernel

Br40

Br40

Contrast

370 mg/mL

370 mg/mL

Volume

90 mL + 30 mL saline

90 mL + 30 mL saline

Flow rate

4 mL/s

4 mL/s

Start delay

1, Arterial phase:
Bolus tracking triggered
at 100 HU in the
abdominal aorta + 3 s
2, Venous phase:
70 s

1, Arterial phase:
Bolus tracking triggered
at 100 HU in the
abdominal aorta + 3 s
2, Venous phase:
70 s

Subscription Button Icon

Keep up to date on the latest trends in healthcare. Read about current developments, new products and upcoming events.