AACC Sponsored Podcast: Laboratory and Clinical Perspectives
Understanding Findings of Sex-specific 99th Percentile URLs for High-sensitivity Cardiac Troponin Assays Derived from Universal Sample Bank
Selection of healthy reference populations and definition of exclusion criteria for deriving 99th percentiles for high-sensitivity cardiac troponin assays used in clinical practice and research vary considerably in the literature. We discuss the Universal Sample Bank findings regarding their clinical implications:
a) Sex-specific 99th percentiles varied according to the statistical method and hs-cTn assay used.
b) Not all assays provided measurable concentrations for women to qualify as hs assays.
c) Surrogate exclusion criteria used to define normality tended to lower 99th percentiles. Participants will learn that the decision concentrations used can affect diagnostics, risk-outcome assessments, and analytical characteristics.
