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  1. Home
  2. Laboratory Diagnostics
  3. Hemostasis
  4. Coagulation Assays
  5. INNOVANCE Anti-Xa assay

INNOVANCE Anti-Xa assaySimplify your anticoagulant testing

The INNOVANCE Anti-Xa assay is an automated chromogenic assay for the quantitative determination of the activity of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) as well as apixaban concentrations in citrated human plasma. The INNOVANCE Anti-Xa assay combines a truly ready-to-use liquid reagent for heparin and direct oral anticoagulant (DOAC) testing, allowing 24/7 access to rapid, specific testing for anticoagulants. Unlike most commercially-available solutions, this assay requires no manual preparation or waiting time. INNOVANCE Anti-Xa assay has now been extended to test for apixaban.

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Siemens Healthineers Hemostasis INNOVANCE Anti-Xa assay

Benefits

Economical testing outcomes
  • Liquid reagents require no manual preparation or reconstitution, allowing staff to concentrate on high-value tasks.
  • Combined testing solution reduces handling, material, and ordering complexity for the lab.
  • Single calibration curve for both types of heparin (UFH and LMWH) streamlines result interpretation and eliminates the risk of evaluation on the wrong curve.
No wait icon
  • 24/7 access to rapid, specific testing for anticoagulants supports timely patient treatment.
  • Robust assay design reduces susceptibility to interferences.
Patient outcomes
  • Drug-specific standards sets for the DOACs apixaban allow for accurate measurement of drug concentrations in ng/mL.
  • Broad and consistent assay range of 0.10 to 1.50 IU/mL for UF and LMW heparin, extendable up to 2.25 IU/mL by sample dilution.
  • High lot-to-lot consistency that helps ensure consistent patient results over time.
Economical testing outcomes
  • Liquid reagents require no manual preparation or reconstitution, allowing staff to concentrate on high-value tasks.
  • Combined testing solution reduces handling, material, and ordering complexity for the lab.
  • Single calibration curve for both types of heparin (UFH and LMWH) streamlines result interpretation and eliminates the risk of evaluation on the wrong curve.

Technical Details

The INNOVANCE Anti-Xa assay offers robust performance across all parameters. With its compact and ready-to-use configuration, the INNOVANCE Anti-Xa assay supports improved laboratory outcomes. It builds on the proven performance of the INNOVANCE Heparin assay and leverages the same proven components, but now also includes DOAC testing capabilities.

Measuring Ranges

Within-device/lab Information

Additional Information

Technical Specifications

0.10–1.50 IU/mL

Consistent measuring range for UFH and LMWH, extendable up to 2.25 IU/mL by sample dilution

20–350 ng/mL

Measuring range for apixaban extendable up to 700 ng/mL by sample dilution

Technical Specifications

0.010 IU/mL

Within-device/lab SD of INNOVANCE Heparin LMW Control 1

0.014 IU/mL

Within-device/lab SD of INNOVANCE Heparin UF Control 1

2.48%

Within-device/lab CV of INNOVANCE Apixaban Control 1

Within-device/lab CV (%) and within-device/lab SD indicated for CS-2500 System. Assay performance can vary from country to country as well as corresponding to the system application of the respective assay. The values listed above are provided as examples only.

Technical Specifications

8 weeks

Stability once opened at 2–8°C

Evidence

Learn more about the individual INNOVANCE Anti-Xa assay components 

By combining heparin and DOAC testing into one simple and easy-to-use assay, the INNOVANCE Anti-Xa assay streamlines handling, reduces order complexity, and offers labs an economical testing outcome.

    Hemostasis Reagent Portfolio cover

    Availability on Systems from Siemens Healthineers

    For details on available assay applications or ordering information, download a copy of the hemostasis reagent portfolio.

    Downloads

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    White Paper: The Influence of Direct Oral Anticoagulants on Coagulation Assays

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    1
    Vandiver JW, Vondracek TG. Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin. Pharmacotherapy. 2012;32(6):546-58.
    2

    Vandiver JW, Vondracek TG. A comparative trial of anti-factor Xa levels versus the activated partial thromboplastin time for heparin monitoring. Hosp Pract. 2013;41(2):16-24.33  

    3

     Liveris A, Bello RA, Friedmann P, Duffy MA, Manwani D, Killinger JS, Rodriquez D, Weinstein S. Anti-factor Xa assay is a superior correlate of heparin dose than activated partial thromboplastin time or activated clotting time in pediatric extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2014;15(2):e72-9.

    4

    Adatya S, Uriel N, Yarmohammadi H, Holley CT, Feng A, Roy SS, Reding MT, John R, Eckman P, Zantek ND. Anti-factor Xa and activated partial thromboplastin time measurements for heparin monitoring in mechanical circulatory support. JACC Heart Fail. 2015;3(4):314-22.

    5

    van Roessel S, Middeldorp S, Cheung YW, Zwinderman AH, de Pont AC. Accuracy of aPTT monitoring in critically ill patients treated with unfractionated heparin. Neth J Med. 2014;72(6):305-10. Free access: http://www.njmonline.nl/getpdf.php?id=1463

    INNOVANCE and all associated marks are trademarks of Siemens Healthcare Diagnostics Inc., or its affiliates. All other trademarks and brands are the property of their respective owners. 
     Product availability may vary from country to country and is subject to varying regulatory requirements. Please contact your local representative for availability.
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