5-minute, low-dose, whole-body, single-bed 18F-FDG delineation of peritoneal carcinomatosis in ovarian carcinoma

5-minute, low-dose, whole-body, single-bed 18F-FDG delineation of peritoneal carcinomatosis in ovarian carcinoma

18.07.2024


By Partha Ghosh, MD, Siemens Healthineers Molecular Imaging, Hoffman Estates, Illinois, USA 
Data and images courtesy of Rigshospitalet, Copenhagen, Denmark

An elderly woman with history of ovarian carcinoma presented with abdominal pain and distention. Further clinical examination revealed gross ascites and abdominal tender­ness. One hour following a 5.6 mCi (208 MBq) intravenous (IV) injection of Fludeoxyglucose F 18 (18F-FDG) Injection, the patient underwent a 5-minute, whole-body, single-bed PET/CT performed on Biograph Vision Quadra™.

Figures 1 to 6 show intense hyper­metabolism within the peritoneal cavity with corresponding omental, mesenteric thickening, multiple macro- and micro-nodules along the bowel loops, peritoneal spaces, peri-colic gutters and liver dome, which show intense diffuse or nodular accumulation of 18F-FDG along with gross ascites, is typical of peritoneal carcinomatosis, which is very typical of ovarian carcinoma. 18F-FDG PET/CT defines the severity of peritoneal carcinomatosis and reflects the typical pattern of carcinomatous peritoneal deposition and serves as a baseline for post-chemo­therapy assessment in this patient in which palliative chemotherapy in the only management choice.

Peritoneal carcinomatosis is common in ovarian carcinoma and colorectal carcinoma as well as in primary gastric carcinoma. Peritoneal involve­ment is a very significant adverse prognostic indicator in these malignancies.

18F-FDG PET/CT has been shown to have high sensitivity for detecting peritoneal malignant deposits which are often associated with intense hypermetabolism even when CT or MRI findings are equivocal and also when differentiation of malignant deposits from physiological bowel uptake is required.1 Peritoneal depos­its on 18F-FDG PET/CT show a variety of patterns ranging from small focal deposits to diffuse involvement. Early peritoneal involvement is character­ized by small irregular focal hyper­metabolic deposits in the mesentery. More advanced peritoneal carcino­matosis shows typical tracer accumu­lation in the infracolic spaces, para­colic gutters, and posterior and inferior hepatic recesses, reflecting the typical pattern of the peritoneal space, which is related to flow of ascitic fluid.

This case shows advanced peritoneal carcinomatosis with the typical pat­tern of involvement of left and right infracolic spaces, pouch of Douglas, left and right paracolic gutters and liver dome, and posterior and inferior hepatic recesses, along with multiple macro- and micro-nodules in the small bowel mesentery as well as in the peri-cecal and peri-sigmoid spaces. This presentation is typical of advanced ovarian carcinoma-related peritoneal involvement.

Long axial field of view (FOV) PET/CT systems provide substantially higher sensitivity compared to standard FOV PET/CT systems. The 106-cm axial FOV along with ultra-fast time-of-flight (TOF) performance of Biograph Vision Quadra enables high image quality PET acquisition at fast imaging times. This is of relevance in patients with suspected peritoneal malignant deposition such as ovarian carcinoma where small peritoneal lesions can be detected with higher contrast due to the high performance of the large axial FOV.2 The 128-slice CT in the Biograph Vision Quadra system also provides high-quality contrast CT for visualization of omen­tal and mesenteric thickening, mac­ro- and micro-nodules for accurate localization and characterization of peritoneal hypermetabolic deposits, and differentiation from physiological uptake.

This case demonstrates how Biograph Vision Quadra achieves a 5-minute, low-dose, single-bed, whole-body 18F-FDG PET/CT delineation of peritoneal carcinomatosis in ovarian carcinoma.

Scanner: Biograph Vision Quadra PET/CT

PET 

 

Injected dose

5.6 mCi (208 MBq) 18F-FDG

Post-injection delay

1 hour

Acquisition

1 bed position/5 minutes per bed

Total scan time: 5 minutes

Reconstruction

440 x 440 matrix, PSF+TOF, 4i5s

 

CT

Tube voltage

100 kV

Tube current

228 ref mAs

Slice collimation

128 x 0.6 mm

Slice thickness

2 mm

Prescribing information 

Please see Indications and Important Safety Information.

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