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Determination of sex-specific 99th percentile upper reference limits for a point of care high-sensitivity cardiac troponin I assay

Fred S. Apple, Karen Schulz, Christian W. Schmidt, Trees S. Y. van Domburg, Judith M. Fonville and Femke K. de Theije

Originally published in Clinical Chemistry and Laboratory Medicine (May 2021) with permission to publish from De Gruyter.

Screenshot of Determination of sex-specific 99th percentile upper reference limits for a point of care high sensitivity cardiac troponin I assay

High sensitivity (hs) cardiac troponin (cTn) assays are defined per the IFCC Committee on Clinical Application of Cardiac Biomarker (C-CB) by the ability to measure ≥ 50% of concentrations greater than the limit of detection (LoD) with an impression of ≤10% at sex-specific 99th percentiles. This study determined the sex-specific 99th percentile upper reference limits for males and females utilizing heparinized plasma from AACC universal sample bank for the Siemens point of care (POC) Atellica® VTLi hs-cTnI immunoassay.