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True TOF technology
Set the standard in PET/CT
With the advent of fast scintillator detectors with lutetium oxyorthosilicate (LSO) crystals, true time of flight (TOF) became a realistic innovation for the clinical setting.
Intensified research since the 2000s focusing on true TOF PET/CT systems has shown numerous advantages that LSO-based TOF brings, such as better definition of small lesions, improved uniformity, reduced noise, and sensitivity gain.
Timing is of the essence: Unlocking the potential of PET/CT with time of flight, presented by Dr. Ian Armstrong.
Watch a series of interviews from key industry experts.
Ziad Burbar, MS
Michael Casey, PhD
Anne Smith, PhD
Sebastian Fuerst, PhD
With the advent of fast scintillator detectors with lutetium oxyorthosilicate (LSO) crystals, true time of flight (TOF) became a realistic innovation for the clinical setting.
Intensified research since the 2000s focusing on true TOF PET/CT systems has shown numerous advantages that LSO-based TOF brings, such as better definition of small lesions, improved uniformity, reduced noise, and sensitivity gain.
The ability to offer true TOF depends on the timing response of the detector. Biograph™ PET/CT scanners’ fast LSO crystals and optimized electronics are designed to convert the analog signal from the crystals into a digital signal that allows measurement of the TOF resolution.
All Biograph PET/CT scanners are TOF-capable, empowering lower doses and faster scan times. By measuring the difference between the detection of each coincidence photon, they can better determine the event location along the line-of-response. This makes small segments of response—increasing the accuracy of locating the annihilation event.
With the development of silicon photomultiplier (SiPM) detectors, PET/CT systems are now able to deliver faster TOF performance, which further reduces the segments of response, helps to better localize each event, and decreases noise within the reconstructed image.
Cardiology
01Liver
01Neurology
01Prostate
01
Data courtesy of University Hospital Erlangen, Erlangen, Germany
Biograph™ mCT PET/CT
PET
Scan acquisition: 200 x 200 matrix, PSF+TOF 2i21s
200 x 200 matrix, PSF 2i12s
TrueV
Scan time: 3 minutes per bed
Injected dose: 68Ga-labelled PSMA ligand[b]
3.1 mCi (116 MBq)
CT
Scan parameters: 100 kV/92 ref mAs
Data courtesy of Manchester University NHS Foundation Trust, Manchester, United Kingdom.
True time of flight (TOF) improves definition and contrast for cardiac imaging with 82Rb
Biograph Vision PET/CT
PET
Scan acquisition: 13.48 minutes
Image reconstruction: 440 x 440 matrix, OSEM+PSF 3i5s
440 x 440 matrix, PSF+TOF 3i5s
All-pass filter
Injected dose: Fludeoxyglucose F 18 (18F FDG) Injection[a]
5.5 mCi (204 MBq)
Data courtesy of Osaka City University Hospital, Osaka, Japan.
Biograph Vision PET/CT
PET
Scan acquisition: 1 bed position/10 minutes
Image reconstruction: 880 x 880 matrix, PSF 8i5s
880 x 880 matrix, PSF+TOF 8i5s
All-pass filter
Injected dose: Fludeoxyglucose F 18 (18F FDG) Injection[a]
4.2 mCi (157 MBq)
CT
Scan parameters: 120 kV/232 ref mAs
Data courtesy of University Hospital Erlangen, Erlangen, Germany
Biograph™ mCT PET/CT
PET
Scan acquisition: 200 x 200 matrix, PSF+TOF 2i21s
200 x 200 matrix, PSF 2i12s
TrueV
Scan time: 3 minutes per bed
Injected dose: 68Ga-labelled PSMA ligand[b]
3.1 mCi (116 MBq)
CT
Scan parameters: 100 kV/92 ref mAs
Data courtesy of Manchester University NHS Foundation Trust, Manchester, United Kingdom.
True time of flight (TOF) improves definition and contrast for cardiac imaging with 82Rb
Biograph Vision PET/CT
PET
Scan acquisition: 13.48 minutes
Image reconstruction: 440 x 440 matrix, OSEM+PSF 3i5s
440 x 440 matrix, PSF+TOF 3i5s
All-pass filter
Injected dose: Fludeoxyglucose F 18 (18F FDG) Injection[a]
5.5 mCi (204 MBq)
Data courtesy of Osaka City University Hospital, Osaka, Japan.
Biograph Vision PET/CT
PET
Scan acquisition: 1 bed position/10 minutes
Image reconstruction: 880 x 880 matrix, PSF 8i5s
880 x 880 matrix, PSF+TOF 8i5s
All-pass filter
Injected dose: Fludeoxyglucose F 18 (18F FDG) Injection[a]
4.2 mCi (157 MBq)
CT
Scan parameters: 120 kV/232 ref mAs
Data courtesy of University Hospital Erlangen, Erlangen, Germany
Biograph™ mCT PET/CT
PET
Scan acquisition: 200 x 200 matrix, PSF+TOF 2i21s
200 x 200 matrix, PSF 2i12s
TrueV
Scan time: 3 minutes per bed
Injected dose: 68Ga-labelled PSMA ligand[b]
3.1 mCi (116 MBq)
CT
Scan parameters: 100 kV/92 ref mAs
The outcomes achieved by the Siemens Healthineers customers described herein were achieved in the customer’s unique setting. Since there is no “typical” hospital and many variables exist (eg, hospital size, case mix, level of IT adoption) there can be no guarantee that others will achieve the same results.
See below for Indications and Important Safety Information for Fludeoxyglucose F 18 (18F FDG) Injection.
The tracer used in this case is a research pharmaceutical. It is neither recognized to be safe and effective by the FDA nor commercially available in the United States or in other countries worldwide. Its future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.
By completing the form below, you are requesting to be added to our list for email communications. The information you provide below will be processed as described further in the Privacy Notice.
Learn more about Biograph PET/CT family
The features herein are not commercially available in all countries. Its future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.
Biograph Vision is not commercially available in all countries. Its future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.
Header image data courtesy of Manchester University NHS Foundation Trust, Manchester, United Kingdom.
