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Home
Medical Imaging
Molecular Imaging and Nuclear Medicine Systems
MI Trends and Innovations
Beta-amyloid PET/CT imaging for Alzheimer's disease

Beta-amyloid PET imaging for Alzheimers disease keyvisual

Beta-amyloid PET/CT imaging for Alzheimer's diseaseIdentify, evaluate, and quantify

Several ground-breaking immunotherapy treatments have recently emerged that work to reduce beta-amyloid plaques that form in the brain and slow down cognitive decline in the early stages of Alzheimer's disease (AD). To qualify for these treatments, the presence of beta-amyloid plaque must be confirmed through diagnostic testing. Beta-amyloid PET/CT imaging plays a critical role in the AD care pathway, as it is one of the only modalities available to evaluate beta-amyloid plaque burden.

AD and beta-amyloid plaque accumulation

In a healthy brain, beta-amyloid protein fragments are broken down and removed from the brain. In a brain with AD, beta-amyloid protein fragments accumulate to form hard, insoluble plaques in between neurons. Beta-amyloid plaque buildup in the brain is often an early indicator of AD. This plaque buildup can be devastating, which is why early detection with a diagnostic tool, such as beta-amyloid PET/CT imaging, is crucial to improving outcomes for patients with AD.

Enabling the AD care pathway

Identify

PET radiopharmaceuticals to image beta-amyloid plaque

Evaluate

PET/CT and PET/MR imaging to evaluate beta-amyloid plaque burden

Quantify

Software solutions to quantify protein deposits in the brain

Identify

PETNET Solutions, Inc., a Siemens Healthineers company, sells and distributes an FDA-approved diagnostic PET tracer for imaging beta-amyloid neuritic plaque density in the brain of adult patients with cognitive impairment who are being evaluated for AD or other causes of cognitive decline.

PETNET Solutions, Inc.

With a comprehensive portfolio of agents for imaging amyloid-beta plaque buildup and other neurological pathologies, and supplied by our reliable delivery network of high-energy radiopharmacies, PETNET Solutions is positioned to support the identification of neurodegenerative diseases like AD in its earliest stages.

Reliable delivery of PET imaging biomarkers

Our dedicated team expertly operates our fully integrated radiopharmacy network in select countries for distribution of imaging biomarkers for neurodegenerative diseases like AD with order delivery reliability exceeding 99%.¹

Ready to support your PET imaging business

Grow your PET imaging business

PETNET Solutions leverages an experienced field staff, averaging more than 20 years of experience in the molecular imaging industry, to help with the successful implementation of new imaging biomarkers. We are ready to support your efforts to plan, operate, and grow your PET imaging business.

Evaluate

Biograph™ PET/CT and PET/MR systems are capable of performing scans to determine eligibility for treatment with approved amyloid-targeting therapies as well as to evaluate amyloid-related imaging abnormalities (ARIA).

Siemens Healthineers Biograph PET/CT scanners featuring Biograph Trinion

Our Biograph family of PET/CT scanners uses optimized components for the detection systems, Optiso High Definition (HD) and Optiso Ultra Dynamic Range (UDR) PET detectors. The design and configuration of the LSO crystals, the high-speed electronics, and the optimal acquisition matrix size, all enable physicians to attain the highest image quality and accurate quantifiable results. Combined with high-definition technologies, such as UltraHD•PET, the images produced allow physicians to confidently evaluate a patient's condition.

For treatment monitoring, MRI plays an instrumental role in detecting the occurrence of ARIA that may result from immunotherapy drug treatment.

Learn more

Optiso detector technology

Designed for optimum performance, our PMT based design offers high volumetric resolution 95-mm³, decreased partial volume effect, and superb image quality.

Crystal element technology

A fast, efficient scintillator, LSO is grown and cut in-house. Crystal elements deliver high isotropic spatial resolution; higher spatial resolution may result in improved lesion detectability.

Time-of-flight technology

Supports to better localize the event within a small range along each line of response (LOR). The better localization of each event using time of flight (TOF) reduces noise in the reconstructed image while improving contrast and image clarity.

ultraHD•PET technology

Provides improved image signal-to-noise by utilizing timing information (TOF) between the two PET coincidence events. Combined with the resolution recovery of HD•PET, this option can be used to enhance image quality.

Beta-amyloid PET image comparison

A positive beta-amyloid PET scan is not a definitive diagnosis for AD but rather a diagnostic tool to determine the presence of beta-amyloid plaques in the brain to help increase the clinical certainty of AD diagnosis. The use of beta-amyloid PET imaging may help enable the quantification of beta-amyloid plaque burden in the brain cortices as well in the blood vessels supplying the brain.²

Data courtesy of Provision Diagnostic Imaging, Knoxville, Tennessee, USA.

Quantify

Alzheimer’s disease is characterized by the accumulation of both beta-amyloid plaques and tau protein tangles in the brain. Deposits of beta-amyloid and tau occur in different regions and at different rates in the aging brain. Together, these pathologies lead to neurodegeneration, which results in cognitive and clinical decline in individuals with AD.

syngo.MI Neurology software enables the measurement of beta-amyloid and tau protein deposits in the brain.

Data courtesy of Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA.

syngo.PET Cortical Analysis features

Centiloid scoring standardizes the quantification of beta-amyloid plaque in PET scans across three commercially available beta-amyloid PET radiopharmaceuticals used to diagnose AD
Tau PET quantification assesses and quantifies the distribution and density of tau protein tangles in the brain from a PET image acquired using the PET radiopharmaceutical

Clinical case studies

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See our complete molecular imaging portfolio

Did this information help you?

Data on file.

Alzheimer's Association. FOR HEALTHCARE PROFESSIONALS. Frequently asked questions about beta-amyloid imaging. Available at https://www.alz.org/media/documents/health-care-pros-faqs-beta-amyloid-imaging.pdf. Accessed October 2023.

The products and features mentioned herein are not commercially available in all countries. Future availability cannot be guaranteed.

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Beta-amyloid PET/CT imaging for Alzheimer's diseaseIdentify, evaluate, and quantify