全自動血漿蛋白検査システム ベーリング ネフェロメータⅡおよびBNプロスペック専用試薬
ネフェロメトリー法を用いて、信頼性の高い結果を簡単な方法で提供します。本試薬は多発性骨髄腫の診断、モニタリングに有用です。
- モノクローナル抗体を使用した高い特異性
- 優れたロット間再現性(小さいロット間差)
- プレ反応プロトコールによる抗原過剰チェック
柔軟性のあるキット構成-試薬、補助試薬、スタンダード、コントロールは別パッケージになっており、無駄を出しません。
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全自動血漿蛋白検査システム ベーリング ネフェロメータⅡおよびBNプロスペック専用試薬
ネフェロメトリー法を用いて、信頼性の高い結果を簡単な方法で提供します。本試薬は多発性骨髄腫の診断、モニタリングに有用です。
柔軟性のあるキット構成-試薬、補助試薬、スタンダード、コントロールは別パッケージになっており、無駄を出しません。
信頼性の高い結果は、患者様のフォロー(診断、治療、モニタリング)に有用です
フリーライトチェーン(FLC)の測定は、2009年より公式に推奨された多発性骨髄腫(MM)のスクリーニングパネルのひとつ *1, *2 です。さらにFLC 測定は、予測情報を提供し、治療効果のモニタリングに有用です。信頼性の高い測定結果の必須事項は、スクリーニングにおいては常に高感度であること、フォローアップにおいては変化を敏感に捉えることです。
良好なロット間再現性と抗原過剰をチェックすることによる安心感が、単クローン性ガンマグロブリン血症患者様のマネジメントを改善できると思いませんか?
N-ラテックス FLC カッパ型とラムダ型は、シーメンスの自動免疫ネフェロメータシステムを用いて信頼性の高い簡単な方法でFLCを検出します。
ロット間差が非常に小さい
抗原過剰チェックを改善
使い易いパッケージ
IFE カッパ陽性 | N-ラテックスFLC カッパ型 | 他社FLC カッパ |
60 | 60(100%) | 59(98.3%) |
IFE ラムダ陽性 | N-ラテックスFLC ラムダ型 | 他社FLC ラムダ |
59 | 59(98.3%) | 56(94.9%) |
IFE,カッパand/or ラムダ陽性 | N-ラテックスFLC 比 | 他社FLC 比 |
115 | 105(91.3%) | 103(89.6%) |
N-ラテックスFLCと他社比較(N=152, 異常低値と異常高値において)
一致率 | コーエン係数 | |
FLC カッパ | 90.1% | 0.76 |
FLC ラムダ | 81.5% | 0.65 |
FLC 比 | 92.2% | 0.87 |
それぞれ3ロットを2つの異なるスタンダードロットで比較(N=95)
性能
測定原理 | ラテックス 免疫比ろう法 |
検体種 | 血清、血漿(ヘパリン、EDTA) |
測定時間 | 12分 |
参照範囲 | FLC カッパ:6.7 - 22.4 mg/L |
総測定範囲 | FLC カッパ:3.4 - 110 mg/L |
初期測定範囲 | 3.5 – 110 mg/L for FLC kappa 1.9 – 60 mg/L for FLC lambda C |
試薬開封後の安定性 | 4週間(2-8℃保存時) |
検量線頻度 | 6週間 |
精密性 | 同時再現性:< 5% ラボ間:< 6.5% |
抗原過剰 | FLC カッパ:23,000 mg/L まで確認されず |
*1 Kyle RA, Raikumar SV; Leukemia 2009; 23: 3-9.
*2 Dispenzieri A, Kyle R, Merlini G, et al.; Leukemia 2009; 23 215-24.
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