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    Point-of-care testing

    Fighting Sepsis at the Point of Care

    3min
    Linda Brookes
    Published on January 25, 2019

    The POC lactate test was added to the epoc device as part of the hospital’s fighting sepsis initiative.

    POC lactate testing is helpful in early sepsis detection.

    Every year, sepsis is diagnosed in over 1.5 million people in the United States and at least 250,000 die from sepsis.[1] Sepsis represents the biggest US hospital expense, totaling around 24 billion USD annually.[2] Nationwide, hospitals are adopting new screening programs to improve rates of early recognition and treatment of sepsis to prevent progression from severe sepsis to septic shock, and reduce the numbers of deaths and length of hospital stays due to sepsis.


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    Lactate tests at the point of care enable early detection and treatment of sepsis.

    The sooner lactate is measured, the earlier sepsis treatment can begin.

    Huntsville Hospital, a 941-bed, publically owned facility in Huntsville, Alabama, has been among the leaders in improving protocols and education focused on sepsis. Kristie M. Campbell, Manager of Point of Care (POC) Testing and Outreach Operations for Huntsville Hospital Laboratory, described how POC testing was integrated into the hospital’s sepsis protocol. “We wanted to expand its services to be truly competitive with other hospitals in the South East region of the U.S., and to ensure that testing was done as efficiently as possible,” she recalled.

    Introduction of point of care testing

    “POC testing has become integrated in how we care for our patients,” Campbell emphasized. “Clinicians want it everywhere that we care for patients in our hospital.” For these “early adopters” of POC handheld technology, the epoc Blood Analysis handheld device represented a “natural progression” of the POC testing that was introduced 22 years ago.” The hospital began using the device in cardiovascular operating rooms and intensive care unit (ICU) in 2009, followed by a phased rollout in other departments and ICUs.


    The POC lactate test was added to the epoc device as part of the hospital’s sepsis initiative. Decreasing the time between taking blood from the patient to the result being available to the clinician (“vein to brain time,” as Campbell likes to call it) is critical. “For every hour you wait to give an antibiotic to a patient, the mortality risk of that patient increases 8%,” she noted. “With a handheld device, the nurse can get test results within 3 minutes.”

    Campbell recalled that on the first floors where the sepsis program was introduced, mortality over the first three to six months decreased by almost 50%, “a very astounding number.” Huntsville Hospital also participated in a study which found that around 5% of patients with an initially negative lactate result (<2.0 mmol/L) went on to develop septic shock. So the recommendation to do a repeat assay within hours after an initial negative assay was adopted.


    The Society of Critical Care Medicine recently issued a new “sepsis bundle,” outlining the steps that should be taken within a critical window of one hour for early identification and appropriate management of sepsis.[3] The new bundle emphasizes how randomized controlled trials have shown that lactate-guided resuscitation leads to a significant reduction in mortality. It directs that measurement of lactate, along with blood cultures, administration of fluids and antibiotics, and, if necessary initiation of vasopressor therapy, all be started immediately. “There would be no way we could meet those milestones and criteria without using POC lactate,” Campbell concludes. “It is crucial to our care for all of our patients in our hospital.”

    Kristie M. Campbell is a strong advocate of point of care sepsis testing.
    By Linda Brookes
    Linda Brookes is a freelance medical writer and editor based in New York and London with a record of working for a wide range of international clients and publications in the healthcare and pharmaceutical fields.
    1. All Online sources last accessed Aug. 21, 2018

    1. Centers for Disease Control and Prevention (CDC). Protect your patients from sepsis. Atlanta, GA: CDC; 2017 https://www.cdc.gov/sepsis/education/hcp-resources.html

    2. Torio C, Moore B. National inpatient hospital costs: The most expensive conditions by payer, 2013. HCUP Statistical Brief #204. Rockville, MD: Agency for Healthcare Research and Quality; 2016. http://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.pdf

    3. Levy MM, Evans LE, Rhodes A.. The Surviving Sepsis Campaign bundle: 2018 update. Crit Care Med. 2018;46:997−1000. http://www.survivingsepsis.org/SiteCollectionDocuments/Surviving-Sepsis-Campaign-Hour-1-Bundle-2018.pdf

    1. The statements by Siemens Healthineers customers described herein are based on results that were achieved in the customer’s unique setting. Since there is no “typical” hospital and many variables exist (e.g., hospital size, case mix, level of IT adoption) there can be no guarantee that other customers will achieve the same results.